Safety data sheet for Acetonitrile
CAS 75-05-8
This is the free preview of a draft SDS for Acetonitrile — Sections 1, 2 and 9, generated from the sources named below. The full 16-section draft, with your own company in Section 1, is $5 per document.
Typically documented by: HPLC and laboratory solvent.
Draft safety data sheet — preview
Sections 1, 2, 9 of 16
- CAS number
- 75-05-8
- Molecular formula
- C2H3N
- Molecular weight
- 41.05 g/mol
- Signal word
- Danger
Hazard classification
- GHS02 — Flammable
- GHS07 — Health hazard — irritant
- H225: Highly flammable liquid and vapor.
- H302: Harmful if swallowed.
- H312: Harmful in contact with skin.
- H319: Causes serious eye irritation.
- H332: Harmful if inhaled.
Section 1 — Identification
1.1 Product identifier
Product identifier: Acetonitrile
Chemical name (IUPAC): acetonitrile
CAS number: 75-05-8
PubChem CID reference: 6342
Synonyms: ACETONITRILE; Methyl cyanide; Cyanomethane; Ethanenitrile; Ethyl nitrile; Methane, cyano-; Methanecarbonitrile; Acetonitril; Cyanure de methyl; Methylkyanid
Section 2 — Hazards Identification
2.1 Classification of the substance or mixture
Classification basis: OSHA 29 CFR 1910.1200 Appendix A, aligned to the GHS Rev. 7 hazard classes this sheet resolves: Flam. Liq. 2, Acute Tox. 4 (Oral), Acute Tox. 4 (Dermal), Eye Irrit. 2, Acute Tox. 4 (Inhalation).
Classification: Flammable Liquid, Category 2 (Flam. Liq. 2) [H225]
Classification: Acute Toxicity, Category 4 — Oral (Acute Tox. 4 (Oral)) [H302]
Classification: Acute Toxicity, Category 4 — Dermal (Acute Tox. 4 (Dermal)) [H312]
Classification: Eye Irritation, Category 2 (Eye Irrit. 2) [H319]
Classification: Acute Toxicity, Category 4 — Inhalation (Acute Tox. 4 (Inhalation)) [H332]
2.2 Label elements
Signal word: Danger
GHS pictograms: GHS02 (Flammable), GHS07 (Exclamation)
Hazard statement: H225: Highly flammable liquid and vapor.
Hazard statement: H302: Harmful if swallowed.
Hazard statement: H312: Harmful in contact with skin.
Hazard statement: H319: Causes serious eye irritation.
Hazard statement: H332: Harmful if inhaled.
Precautionary statement: P210: Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
Precautionary statement: P264+P265: Wash hands thoroughly after handling. Do not touch eyes.
Precautionary statement: P280: Wear protective gloves, protective clothing, eye protection, face protection, and hearing protection.
Precautionary statement: P303+P361+P353: IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower.
Precautionary statement: P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
Precautionary statement: P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
Section 9 — Physical and Chemical Properties
9.1 Information on basic physical and chemical properties
Physical form: Liquid
Appearance: Colorless, limpid liquid
Odor: Aromatic odor
Boiling point: 81.6°C (179°F) at 1013 hPa
Melting point: -44°C (-47°F)
Flash point: 2°C (36°F) closed cup
Density: Specific gravity: 0.78745 at 15 °C/4 °C
Vapor pressure: 97.3 hPa at 20°C
Water solubility: Miscible
Log Pow (log Kow): -0.34
Vapor density: 1.42 (air = 1)
Lower explosive limit: 3.0% (v/v in air)
Upper explosive limit: 16.0% (v/v in air)
Auto-ignition temperature: 524°C (975°F)
Viscosity: 0.35 cP at 20°C
pH: Not available
Occupational exposure limits for Acetonitrile
The airborne limits on public record in the United States. These are transcribed from the tables named in each row, not derived. The full draft puts them in Section 8 with the control and PPE guidance.
OSHA PEL — TWA (8 h)
40 ppm (70 mg/m³)
OSHA Annotated PEL Table Z-1
NIOSH REL — TWA (up to 10 h)
20 ppm (34 mg/m³)
OSHA Annotated PEL Table Z-1 (NIOSH REL column)
Where each value came from
- Odor — Hazardous Substances Data Bank (HSDB)
- NIOSH. NIOSH Pocket Guide to Chemical Hazards. Department of Health & Human Services, Centers for Disease Control & Prevention. National Institute for Occupational Safety & Health. DHHS (NIOSH) Publication No. 2010-168 (2010). Available from: https://www.cdc.gov/niosh/npg
- View the record
- Boiling point — Hazardous Substances Data Bank (HSDB)
- O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Cambridge, UK: Royal Society of Chemistry, 2013, p. 14
- View the record
- Melting point — Hazardous Substances Data Bank (HSDB)
- Haynes, W.M. (ed.). CRC Handbook of Chemistry and Physics. 94th Edition. CRC Press LLC, Boca Raton, FL: 2013-2014, p. 3-6
- View the record
- Density — Hazardous Substances Data Bank (HSDB)
- Same reference as boiling point above.
- View the record
- Water solubility — Hazardous Substances Data Bank (HSDB)
- Same reference as boiling point above.
- View the record
- Log Pow (log Kow) — Hazardous Substances Data Bank (HSDB)
- Hansch, C., Leo, A., D. Hoekman. Exploring QSAR - Hydrophobic, Electronic, and Steric Constants. Washington, DC: American Chemical Society., 1995, p. 4
- View the record
- Vapor density — Hazardous Substances Data Bank (HSDB)
- Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994, p. 3141
- View the record
- Lower explosive limit — Hazardous Substances Data Bank (HSDB)
- Same reference as odor above.
- View the record
- Auto-ignition temperature — Hazardous Substances Data Bank (HSDB)
- National Fire Protection Association; Fire Protection Guide to Hazardous Materials. 14th Edition, Quincy, MA 2010, p. 325-10
- View the record
- Viscosity — Hazardous Substances Data Bank (HSDB)
- DeVito SC; Nitriles. Kirk-Othmer Encyclopedia of Chemical Technology. (1999-2014). New York, NY: John Wiley & Sons. Online Posting Date: Sept 14, 2007
- View the record
A value with no row here was assembled from more than one record, so no single record is credited for it. The draft you buy carries this table as an appendix covering all 16 sections.
Sources
- ECHA C&L Inventory — harmonised CLP entry
- Hazardous Substances Data Bank (HSDB)
- OSHA Annotated PEL Table Z-1
- OSHA Annotated PEL Table Z-1 (NIOSH REL column)
- PubChem — GHS classification
- PubChem — compound record
- PubChem — names and identifiers
- PubChem — regulatory information
- PubChem — toxicity data
- PubChem — transport information
Sections 1.3 and 1.4 are withheld here because the supplier and emergency contact blocks carry your own company details in the draft you buy. Every draft needs review by a competent person before it is issued.
Measured values for Acetonitrile, and where each one comes from
34 measured values for 12 properties, read from 4 public databases. On 5 properties the records differ. Each reading is shown with its own record. Follow any record to read the value at its source.
Boiling point
5 records, 20 to 82 °C
Used with vapour pressure to judge how readily the substance reaches the air you breathe.
- 81.6 °C at 760 mm Hg
- Hazardous Substances Data Bank (HSDB)
- Burns with luminous flame; dielectric constant: 38.8 at 20 °C; constant boiling mixture with water contains 16% H2O and bp: 76 °C
- Hazardous Substances Data Bank (HSDB)
- 179 °F
- NIOSH Pocket Guide
- 81.65 °C @760 [mm Hg]
- PAC Chemical Database, U.S. Department of Energy
Melting point
4 records, -45 to -44 °C
Fixes the physical state at handling temperature, which the label and the transport class depend on.
- -49 °F
- NIOSH Pocket Guide
Flash point
3 records agree
The lowest temperature at which the liquid gives off enough vapour to ignite. It decides the GHS flammable liquid category.
- 42 °F (6 °C) (Open Cup)
- Hazardous Substances Data Bank (HSDB)
- (oc) 42 °F
- NIOSH Pocket Guide
- 42 °F (open cup)
- OSHA Occupational Chemical Database
Auto-ignition temperature
1 record
The temperature at which the substance ignites with no spark or flame. It sets safe surface and process temperatures.
- 975 °F (524 °C)
- Hazardous Substances Data Bank (HSDB)
Explosive limits
1 record
The vapour concentration range in air that will burn. Below the lower limit and above the upper limit it will not.
- Upper explosive limit 16% and lower explosive limit 3% by vol (at room temp)
- Hazardous Substances Data Bank (HSDB)
Vapour pressure
4 records differ
The higher it is, the faster the substance evaporates into the workplace air at room temperature.
- 88.8 mm Hg at 25 °C
- Hazardous Substances Data Bank (HSDB)
- 73 mmHg
- NIOSH Pocket Guide
- 73 [mm Hg] @20 °C
- PAC Chemical Database, U.S. Department of Energy
Vapour density
2 records differ
Above 1 the vapour sinks and collects in pits, sumps and low enclosed spaces.
- 1.42 (Air = 1)
- Hazardous Substances Data Bank (HSDB)
Density
5 records differ
Needed to convert between mass and volume on the label, in transport papers and in a spill estimate.
- Specific gravity: 0.78745 at 15 °C/4 °C
- Hazardous Substances Data Bank (HSDB)
- Percent in saturated air: 9.6; Density of saturated air: 1.04 (Air = 1)
- Hazardous Substances Data Bank (HSDB)
- 0.786 @ 20°C
- PAC Chemical Database, U.S. Department of Energy
Solubility
5 records, each a different case
Determines spill behaviour, the right extinguishing media and the correct first-aid rinse.
- In water, >800 g/L at 25 °C
- Hazardous Substances Data Bank (HSDB)
- In water, infinite solubility at 25 °C
- Hazardous Substances Data Bank (HSDB)
- Soluble in alcohol
- Hazardous Substances Data Bank (HSDB)
- For more Solubility (Complete) data for ACETONITRILE (6 total), please visit the HSDB record page
- Hazardous Substances Data Bank (HSDB)
- Miscible
- NIOSH Pocket Guide
Partition coefficient (log Kow)
1 record
Indicates whether the substance accumulates in fat or in water, which drives the environmental sections.
- log Kow = -0.34
- Hazardous Substances Data Bank (HSDB)
Viscosity
1 record
Governs how far a spill spreads and how fast it soaks into a surface or a sorbent.
- 0.35 cP at 20 °C
- Hazardous Substances Data Bank (HSDB)
Odour
2 records, each a different case
Odour is a warning property only. Many substances are hazardous well below the concentration you can smell.
- Aromatic odor
- Hazardous Substances Data Bank (HSDB)
- Sweet, ethereal odor
- Hazardous Substances Data Bank (HSDB)
These are the public records read for Acetonitrile, published here unchanged. Where two records disagree, the draft you buy states the value and names the record behind it, so a reviewer can see what was chosen. Every draft needs review by a competent person before it is issued.
Get the full draft SDS for Acetonitrile
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